Poly L-lactic acid (PLLA) is an important biodegradable polymer material. It is non-toxic, non-irritating, biodegradable and absorbable, high strength, good plasticity, and easy to process. The degradation cycle is 2 to 12 months, and the degradation cycle can be changed according to the addition of different modifiers. PLLA is enzymatically decomposed in the body and eventually forms carbon dioxide and water, which has good biocompatibility.
PLLA is a very efficient collagen regenerator, and its safety and effectiveness have been certified by the US FDA, China CFDA, EU CE and other parties.
Unlike hyaluronic acid fillers that take effect immediately, the effect of PLLA is slowly manifested. Over time, plla can gradually stimulate the production of collagen and maintain skin firmness and elasticity through collagen.
Because ultraviolet rays are the killer of collagen, it is crucial to develop correct sun protection habits. When long-wave ultraviolet rays UVA penetrate into the dermis, free radicals are formed, which attack fibroblasts. Immune cells will come to the rescue, but the matrix metalloproteinases in these rescue systems will destroy the collagen fiber structure. Especially when the newly regenerated collagen has not yet been deposited and polymerized into fiber bundles, it is easy to be degraded and destroyed.
The collagen in the connective tissue of the skin is mainly type I collagen, which is synthesized by nearly 18 amino acids. It even requires 7 of the 8 essential amino acids that the human body cannot synthesize on its own. Therefore, the intake of protein foods in the diet must be complete and diversified, and nutritional supplements containing polyamino acids or small molecule peptides can also be supplemented during the treatment stage.
Fibroblasts in the skin are responsible for synthesizing collagen. To synthesize collagen, three independent amino acid chains must be cross-linked into a triple helix structure. The cross-linking agent is the covalent bond between proline and hydroxyproline. However, hydroxyproline must be formed by the hydroxylation of vitamin C. Simply put, lack of vitamin C will be detrimental to the synthesis of triple helix collagen. After synthesis, exocytosis sends these collagens to the intercellular matrix, where these collagens are deposited and cross-linked into fibroblasts. Then, the fibroblasts are cross-linked into solid collagen fiber bundles to support the entire connective tissue.
Singderm Poly-L-Lactic Acid Filler For Injection is a dermal tissue filler, administered by injection into the deep layers of the dermis to achieve wrinkle-filling effects. This Plla Injection Filler is a white lyophilized powder, requiring reconstitution with sterile water for injection to form a suspension. Singderm can stimulates collagen regeneration for nasolabial areas. With the increase in age, skin cell vitality diminishes, collagen gradually decreases, and aging symptoms such as "depression," "looseness," and "sagging" appear on the skin. Singderm injectable PLLA filler is for solve these skin problems. With PLLA in it, it can continuous stimulation for collagen regeneration.
The field of dermal fillers is evolving as technology advances and research deepens.
Take poly-L-lactic acid, for example. This material is known for its collagen-stimulating properties. In the future, poly-L-lactic acid may be used more widely, and its performance and effects may be further improved.
In aesthetic treatments, poly-L-lactic acid (PLLA) injectable fillers offer an innovative way to achieve facial fullness and long-lasting, natural results by stimulating facial collagen production. Poly-L-lactic acid has become a popular choice for facial fillers.
However, it is crucial to fully understand the benefits, uses, and potential risks of poly-L-lactic acid treatments so that you can make an informed decision and consult a medical professional to determine if this filler is right for you.
